DePaul vs Butler prediction, odds, line, spread: Proven model reveals college basketball picks, best bets

A Big East battle is on tap between the DePaul Blue Demons and the Butler Bulldogs at 9 p.m. ET on Tuesday, Feb. 15 at Wintrust Arena. DePaul is 12-11 overall and 9-5 at home, while Butler is 12-13 overall and 2-5 on the road. 

The Blue Demons are favored by 3.5 points in the latest DePaul vs. Butler odds from Caesars Sportsbook, and the over-under is set at 129. Before you make any Butler vs. DePaul picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated DePaul vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins DePaul vs. Butler? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!