Connecticut vs. Syracuse odds, line, spread: Proven model reveals college football picks, predictions for Week 2, 2022

The UConn Huskies will take on the Syracuse Orange at 7 p.m. ET on Saturday at Rentschler Field. The game will air on CBS Sports Network, and the Huskies are 1-1 while 'Cuse is 1-0. UConn ended last year with a 1-11 record, while the Orange ended up 5-7. 

The Orange are favored by 22.5 points in the latest Connecticut vs. Syracuse odds from Caesars Sportsbook, and the over/under is set at 49. Before you make any Syracuse vs. Connecticut picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has simulated Connecticut vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Connecticut vs. Syracuse? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!