College football odds, lines, spreads: Picks, predictions, betting advice for Week 10, 2025 from proven model

No team tops No. 1 Ohio State in the AP Poll, and no team tops the Buckeyes in regard to college football spread success. Entering the Week 10 college football schedule, the Buckeyes have just one ATS defeat, which is tied for fewest in the nation. Those making Week 10 college football picks and seeking college football betting advice may be interested in knowing that OSU's Saturday opponent, Penn State, is tied for the fewest ATS wins with just one. The college football Week 10 odds have the Buckeyes favored by 20.5 points over the Nittany Lions.

Other rivalry games to make Week 10 college football predictions on include the Army vs. Air Force, which has the Falcons favored by 1.5 points, and Georgia vs. Florida (+7). Newer conference matchups that hope to one day be fierce rivalries include Texas vs. Vanderbilt (+3), Oklahoma vs. Tennessee (-2.5) and USC vs. Nebraska (+4.5). 

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Additionally, no game has a higher over/under than Mississippi State vs. Arkansas, with a total of 65.5, as the Hogs are 4.5-point favorites. Meanwhile, the lowest total belongs to Central Michigan vs. Western Michigan (-5.5, 42.5) (see more college football lines right here). 

Before making any college football picks for those games or others in Week 10, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 10 game, and the results are in. 

One of the college picks the model is high on during Week 10: Notre Dame (-30.5, 55.5) covers the massive line versus Boston College in a 3:30 p.m. ET Saturday kickoff well over 50% of the time. Another prediction: Ole Miss (-12.5, 55.5) covers against South Carolina in over 50% of simulations Saturday at 7 p.m. ET, with the Under hitting well over 60% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple upsets in major games, including a ranked favorite losing straight up! 

So which college football teams should you back in Week 10, and which ranked squad falls to an unranked one? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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