Boston College vs. Clemson odds, line, spread: Proven model reveals college football picks, predictions for Week 6, 2022

An ACC battle is on tap between the Boston College Eagles and the No. 5 Clemson Tigers at 7:30 p.m. ET on Saturday at Alumni Stadium. Clemson remained unbeaten with a 30-20 win over then-No. 10 NC State last week. The Tigers are favored by 20.5 points in the latest Boston College vs. Clemson odds from Caesars Sportsbook, while the over/under is set at 48.5. 

Before you make any Clemson vs. Boston College picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Boston College vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Boston College vs. Clemson? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!