2021 NCAA Tournament Sweet 16 Simulation: Model on epic run reveals March Madness bracket picks, predictions

In this bracket, the team that wins more than 50 percent of computer simulations is picked to advance each round. Our optimal bracket beat almost 90% of CBS Sports Bracket Challenge players over the past two years.

SportsLine Staff

No. 1 seed Baylor is a strong pick to come out of this region after cruising to victory in its first two matchups in the 2021 NCAA Tournament. The Bears are our second-best team in neutral-site power ranking, and they've won 18 of their last 20 games. Baylor is winning the title in over 18 percent of our simulations, the second-best chance of any team remaining in the 2021 NCAA Tournament.

Get every pick, every play, every upset and fill out the rest of your bracket with our help! ... Join SportsLine now to see which No. 2 seed is a must-back, which region features a shocking upset in the Sweet 16, and which surprising team advances to the Elite Eight, all from the model that nailed 15 of the 26 double-digit upsets the last four tournaments and still has all four of its Final Four teams alive!