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The Steelers and Colts have the toughest schedules in 2008.
| 2008 NFL STRENGTH OF SCHEDULE | |||
| Team | Opponents' 2007 win pct. | Opponents' 2007 wins | Opponents' 2007 losses |
| Steelers | .598 | 153 | 103 |
| Colts | .594 | 152 | 104 |
| Jaguars | .559 | 143 | 113 |
| Vikings | .551 | 141 | 115 |
| Ravens | .551 | 141 | 115 |
| Bengals | .547 | 140 | 116 |
| Texans | .547 | 140 | 116 |
| Browns | .547 | 140 | 116 |
| Lions | .543 | 139 | 117 |
| Titans | .543 | 139 | 117 |
| Bears | .531 | 136 | 120 |
| Packers | .531 | 136 | 120 |
| Redskins | .523 | 134 | 122 |
| Cowboys | .523 | 134 | 122 |
| Eagles | .520 | 133 | 123 |
| Giants | .520 | 133 | 123 |
| Rams | .488 | 125 | 131 |
| 49ers | .484 | 124 | 132 |
| Seahawks | .477 | 122 | 134 |
| Buccaneers | .469 | 120 | 136 |
| Cardinals | .465 | 119 | 137 |
| Dolphins | .465 | 119 | 137 |
| Panthers | .465 | 119 | 137 |
| Falcons | .461 | 118 | 138 |
| Jets | .457 | 117 | 139 |
| Chiefs | .453 | 116 | 140 |
| Bills | .449 | 115 | 141 |
| Saints | .449 | 115 | 141 |
| Broncos | .445 | 114 | 142 |
| Raiders | .438 | 112 | 144 |
| Chargers | .422 | 108 | 148 |
| Patriots | .387 | 99 | 157 |
