The Seahawks have allowed 17 points through two games. ...

The 49ers are averaging 31 points per game. ...

There were many reasons why the Colts' defense got embarrassed in Week 1. Among them: safety Cam Bynum wore the green dot. Indy's defense had trouble getting lined up properly, including not being set for the first play from scrimmage when Zay Flowers made a 49-yard catch. Defensive coordinator Lou Anarumo is going with LB Akeem Davis-Gaither as his signal caller Sunday night, which should lead to better results. Anarumo has had much more career success vs. Patrick Mahomes than he has against Lamar Jackson. Look for Jonathan Taylor and Alec Pierce to lead the way as the Colts keep this close.

The Seahawks had extra time to get Drew Lock ready for this start against a beatable Arizona defense. Defensively, Seattle held New England to 4.1 yards per play and a miniscule 4.7 yards per pass. Emerging star safety Nick Emmanwori, who missed the season opener with an ankle injury, is practicing and should play Sunday. Back the defending champs to improve to 13-4-1 ATS on the road under Mike Macdonald.

Caleb Douglas, the first rookie wideout drafted by Miami this year, led the team with 94 receiving yards in Week 1. He drew seven targets, one fewer than Malik Washington. Douglas, a 6-4, 205-pounder out of Texas Tech, created good separation and was on the field for all but five offensive snaps. With the Dolphins expected to be trailing throughout, look for Douglas to notch at least 40 receiving yards.

Jacksonville is coming off a dominant offensive performance, the team's ninth straight regular-season win. These same Jaguars put up 34 points in their win in Denver last season. That was the only regular-season home game the Broncos lost. Denver missed a ton of tackles in its Monday night loss in Kansas City. Those can be corrected, given the Broncos' elite personnel. Sean Payton is excellent coming off a loss. And with a rest disadvantage during his Broncos' tenure, Payton is 8-3 ATS, winning those games on average by a touchdown. Look for Denver to bounce back at home and avenge last season's home loss.

The Saints have been feisty lately under Kellen Moore and Tyler Shouck, especially on the road where they’ve covered six straight. They were robbed of an apparent defensive touchdown early in last Sunday's 31-30 overtime loss in Detroit. Baltimore dominated the Colts in Week 1 but is dealing with key injuries at wideout that could limit the Ravens’ explosiveness. While the Ravens rolled up 506 yards, it came against a disorganized defense that couldn't get lined up correctly, in part due to Colts safety Cam Bynum wearing the green dot. Expect a competitive game and grab the points before this line falls.

With Jordan Mason landing on IR, Aaron Jones will lead the Vikings' backfield, ahead of rookie Demond Claiborne and journeyman DeeJay Dallas. In Week 1 the Bears gave up 86 receiving yards to Panthers' running backs. Jones excels as a receiver and should draw at least three targets in this matchup.

This line likely closes lower. The Jets showed in Week 1 that they've improved following last season's 3-14 debacle, while the Packers remain winless (0-6) since losing Micah Parsons late last season. No. 2 overall pick David Bailey had six pressures and a sack for the Jets, who held Tennessee to 4.0 yards per play. I'll be looking to keep backing the Jets as long as Breece Hall and Garrett Wilson remain healthy.

Rain is in the forecast but I still like Geno Smith to exceed this relatively modest number. Smith didn’t need to throw much last week in Tennessee. He’ll need to throw more in this matchup. Garrett Wilson looks 100 percent healthy. Given the continued absence of Micah Parsons, Smith should operate from a clean pocket on most dropbacks.

Landon Dickerson wasn't playing well before he landed on IR, but his absence has caused the Eagles to shuffle their offensive line Sunday. Drew Kendall moves to center, with Cam Jurgens taking over at guard for Dickerson. That could spell trouble vs. Jeffery Simmons and co. Philly mustered only 10 first downs in Week 1 under new coordinator Sean Mannion. While the Eagles should get out of Nashville with a win, I bet the Titans to keep it respectable.

DJ Moore might not be a prototypical No. 1 receiver, but he is unquestionably the Bills' top wideout. And this Lions' defense just gave up 182 receiving yards to Chris Olave. The Lions remain without safeties Brian Branch and Kerby Joseph, and on Tuesday they added corner D.J. Reed to the injury report, listing him as limited with a foot injury. Even if he suits up, I love Moore to notch 60-plus receiving yards in what should be a shootout.

Kenneth Walker's backups are fifth-round rookie Emmett Johnson and pass-catcher Brashard Smith. The Chiefs are starting undrafted rookie Khalil Benson at left tackle. He's a better run-blocker than pass-blocker, and he'll struggle against Denver's Nik Bonitto (27.5 sacks last two seasons). With Patrick Mahomes returning from a torn ACL and LCL, look for the Chiefs to lean on their big free-agent acquisition. Even if Walker is inefficient early, Andy Reid will stick with him because Walker always is a threat to bust a long run.

Bo Nix says he won't hesitate to run this season, despite the fact he's coming back from a fractured right ankle. In Kansas City last season, he rushed nine times for 42 yards. In each of his two previous NFL season openers, Nix shown a willingness to run. Look for Nix to scramble enough to clear this discounted number.

I trust Kevin O’Connell to design an offense around Kyler Murray’s strengths. While Murray’s acquisition dominated offseason coverage, Minnesota made a defensive move that could prove almost as important, signing James Pierre. The former Steeler graded out last season as the NFL’s top cover corner, per PFF. The Packers could get off to a slow start until their offensive line comes together and Micah Parsons returns.