NFL Week 1 betting trends, odds, leans, totals: Bettors hammering 49ers cover vs. Lions, Vikings cover vs. Bengals; Packers-Saints taking biggest over total action

Here are updated betting trends for NFL Week 1 from Caesars Sportsbook.
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Even though NFL Week 1 home underdogs have covered the spread in 29 of their past 40 instances and the fact that the San Francisco 49ers are the biggest road favorites of any team Sunday at -8 in Detroit, bettors at Caesars Sportsbook are wagering more money on the spread on the Niners than any other Week 1 club to the point the number has risen from -7.5 and could get as high as -9 by the 1 p.m. ET kickoff from Ford Field.

Ninety percent of all money wagered on the 49ers-Lions spread is on San Francisco and about 80 percent of tickets sold. That's fairly unusual, frankly, for such a big road favorite this early in a season, although the Lions are expected to be one of the worst teams, if not the worst, in the NFL this year. Keep in mind that San Francisco is just 1-11-1 ATS in its past 13 as at least a TD favorite anywhere. In the past 10 seasons, teams favored by at least eight points anywhere in Week 1 are 5-14 ATS.

The total is set at 45 for the game and has dropped from 46 because it's also taking one of the biggest Under leans of Week 1 with 75 percent of all money and 68 percent of tickets on the Under.

The Minnesota Vikings opened as 2.5-point favorites at the Cincinnati Bengals but are up to -3 as 89 percent of all money wagered on the spread and 79 percent of tickets are on the Vikes. Minnesota finished last season on a seven-game ATS losing streak, and that's the longest such active skid in the NFL. The Vikings have not lost eight straight games ATS since losing 10 in a row from 1978-79.

Sunday will be the return from a serious knee injury of Bengals second-year QB Joe Burrow, who attempted only one pass this preseason. Burrow was 2-7-1 SU and 6-4 ATS in 10 starts as a rookie before going down.

In two seasons under Coach Zac Taylor, the Bengals are NFL-worst 6-25-1 SU and 15-17 ATS. They have covered nine games without winning in that span, the most in the NFL. Taylor is on one of the hottest coaching seats in the league and if the Bengals get trucked at home Sunday, that will only get hotter.

The game taking the heaviest Under lean on Sunday is Jaguars-Texans with a total of 45.5 in Trevor Lawrence's regular-season debut. Ninety-five percent of money wagered on that total is on the Under. That's a bit curious considering the Jaguars have tied an NFL record by allowing at least 24 points in 15 straight games.

On the flip side, the matchup taking the heaviest Over lean is Packers-Saints in Jacksonville, Fla. On the total of 50, a whopping 97 percent of the money wagered is on the Over. The Over is 9-1 in the past 10 in this series.

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Matt SeveranceSeverance Pays