Jameis Winston is in this game, which means there's a good chance the total is going Over. Bucs games have gone Over 9 of 12 times this season, and the Colts will be missing multiple DBs due to injury. Indy hasn't been scoring a lot lately, but Tampa's pass D isn't very good and the Colts could be playing catch-up. There's also the chance Winston could throw a pick-six at any moment. Take the Over.

The Colts will try to pound the ball as usual, but the Bucs' defense is elite against the run. Kenny Moore's absence will hurt Indy in this matchup, as the Bucs trot out three dangerous wideouts plus O.J. Howard. Lay the points as Indy, minus T.Y. Hilton, continues to be fade material.

I like the way the Bucs are playing. Their defense is stepping up, and Jameis Winston has come along. The Colts can't do much without T.Y. Hilton. They've scored 17 or fewer points in three of their last four games. Lay the field goal.