The Lions' D-line will make the difference in this one, capitalizing on a bad Chargers O-line. LA is the better team if healthy, but the Chargers are missing too many key performers. Back the home dog.

It hurts a bit to back the Lions after watching them blow a 24-6 fourth-quarter lead last week, but there’s too much in Detroit’s favor here. The Chargers will be without Hunter Henry and possibly Mike Williams (not to mention Derwin James, Melvin Gordon, the list goes on … even their kicker is questionable). L.A. allowed 203 yards rushing per game last season, and last week the Colts went for exactly 203. This should be Kerryon Johnson's game. A home dog facing a beat-up team? Take the points.

With all the injuries the Chargers are dealing with, I have to be on the Lions in this game, regardless of how poorly Matt Patricia showed in the fourth quarter last week. It's possible the Chargers will be down two of their top pass catchers with Hunter Henry out and Mike Williams not practicing, and they're already missing multiple key players. Detroit wants to be a running offense, and after Marlon Mack rolled in Week 1, that will likely be the model for their gameplan in this game. The Lions defense plays four quarters this week and gives the team a win.

Austin Ekeler is a real matchup problem, as he showed in Week 1, and now he'll get to attack a Lions defense that collapsed late at Arizona. The Chargers' defense impressed me even without Derwin James. Lay the small number with the much better team.