The Titans looked great in Week 1, partly because they were able to rough up the Browns' O-line, but that won't happen against the Colts. Tennessee took advantage of two Browns weaknesses (OL and run defense) that are Colts strengths, and Indy has always had the Titans' number (12-2 vs. Tennessee since 2012). Jacoby Brissett and the Colts should've beaten the Chargers on the road; take the 3 against a team they own.

I was impressed with the way Colts QB Jacoby Brissett played last week on the road in the crunch to force the game into overtime. But The Titans' defense did an amazing job on the Browns' offense. This could be a letdown spot after such a huge win, but I think the energy of the home opener will keep them pumped. The Colts beat them down in both meetings last season, so they’ve got that motivating factor going for them. I made the game -4.5, so I’m happy to lay only -3 with the Titans.