Simulation Picks
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Expert Picks
The Cardinals' biggest issue was the offensive play-calling, as running David Johnson into the middle of the line just isn't a smart use of his talents. With Bruce Arians disciple Byron Leftwich in charge, I expect a much better showing from the offense. The defense shined in a road matchup with the 49ers a few weeks ago, and I expect more of the same here. The 49ers just aren't getting turnovers, and the Cardinals defense is too good to drive the field on repeatedly. Cardinals should be favored in this matchup.
Arizona is awful, while the 49ers have a good young team. It's that simple.
With new offensive coordinator Byron Leftwich calling the plays now, many in the media believe that things will magically change for the Cardinals. Maybe there will be an uptick in creativity on offense, but there are still some concerns with the defensive personnel and QB Josh Rosen has been turnove- prone and now has a banged up toe. The 49ers, on the other hand, seem to find ways to make offense happen despite clear personnel shortcomings.