The 0-4 Arizona Cardinals are coming off consecutive home covers against the Bears and Seahawks. Both games were done with hardly any offense to show for. They’ll travel to San Francisco to take on a team that did not skip a beat with CJ Beathard at quarterback in last week’s matchup against the Chargers. Look for Josh Rosen to perform better and the Cardinals to cover the small number.

It might seem crazy to lay points with C.J. Beathard, but this is Josh Rosen's first road start and we can expect some key mistakes. Arizona ranks dead last in offense, and the Cards' defense is below average as well. Lay it.

When the QB matchup is a rookie (Arizona’s Josh Rosen) and a backup (San Francisco's C.J. Beathard), anything can happen. The tipping point is the 49ers’ battered offensive line, with three-fifths of the starters -- LT Joe Staley, RT Mike McGlonchey and C Weston Richburg -- dealing with knee injuries. Rosen showed poise in his first start last Sunday. For a matchup with an ultra-low total of 40, taking more than a field goal is inviting.