Jared Goff and Todd Gurley aren't playing, and other key Rams starters will be rested too. Back San Fran to win its fifth straight behind Jimmy Garoppolo.

It appears the Rams are going to wisely use Week 17 to give key players some rest and avoid any crippling injury heading into the playoffs rather than go all-out to earn the three seed instead of the four seed. The four may actually be the better spot if the Philly team from Monday night is the same one that shows up for the playoffs. The 49ers have everything to play for, as a win would mean they end the season undefeated, with a 5-0 record since Jimmy Garoppolo took over at QB. San Francisco was a failed two-pointer away from OT in Week 3 against a max-effort Rams team, and they should be able to win here.