The bye came at the right time for the Cardinals, who needed to re-charge. The 49ers have been blown out on consecutive weeks and could use a break of their own. Look for a big game from Adrian Peterson as Arizona beats San Fran for the sixth straight time.

The 49ers failed to score a touchdown against Arizona five weeks ago, even while playing overtime, and another TD-free game is possible. Inexperienced QB C.J. Beathard is under persistent siege behind a Swiss-cheese line and has no playmakers to bail him out. The string of tight 49ers straight-up defeats has given way to romps, and the Cardinals will provide little relief. Arizona returns off a bye and, though QB Carson Palmer is done for the season, Drew Stanton is 6-3 outright as a fill-in starter.

Look, the 49ers are going to win a game this year; 99.9 percent of teams do. And what better spot to do it than at home against a Cardinals team that's now lost its star running back and starting quarterback? These two teams played in Arizona back when Carson Palmer was still on the team, and the only lead the Cardinals had in that game was at the final whistle, scoring a TD with 32 seconds left in overtime. Take away that 38-point showing against a beat-up Bucs defense and the Arizona offense has been getting worse and worse all season. Take the points with a team that has played a lot of close games this year.

Newly acquired QB Jimmy Garoppolo won't be ready to take the helm for the Niners yet, so we get C.J. Beathard against Arizona's Drew Stanton, who fills in for the injured Carson Palmer. My projections have San Francisco earning its first win in 58 percent of simulations, and covering 61 percent of the time. Take the Niners and the points.