The Minnesota Vikings opened up their 2021 season on the road against the Cincinnati Bengals and fell short in a thrilling 27-24 loss at Paul Brown Stadium. They'll get a chance at redemption on Sunday against the red-hot Arizona Cardinals, who blew out the Tennesee Titans 38-13 in Week 1. Kickoff at State Farm Stadium is set for 4:05 p.m. ET. Arizona is a 3.5-point favorite in the latest Cardinals vs. Vikings odds at Caesars Sportsbook. The over-under for total points is 50.5. (See the latest NFL lines for every game this week on our NFL odds page.)

Before making any Vikings vs. Cardinals picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Vikings vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Vikings vs. Cardinals on Sunday? And which side of the spread cashes in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Vikings vs. Cardinals spread you need to jump on, all from the model on a 121-79 roll on NFL picks!