Rising star Ciryl Gane faces battle-tested veteran Derrick Lewis for the interim heavyweight title on Saturday in the main event of UFC 265 from the Toyota Center in Houston. The main card is set for 10 p.m. ET. Gane is a -380 favorite (risk $380 to win $100), while Lewis is a +310 underdog (risk $100 to win $310) in the latest UFC 265 odds from Caesars Sportsbook.

The third-ranked Gane (9-0) has impressed with athleticism and agility that are rare for an athlete who regularly tips the scales at or near the heavyweight limit of 265 pounds. The French fighter has run through his first six UFC opponents but was pushed to the distance in each of his last two fights. 

Lewis (25-7-1) is known for his one-punch knockout power and his irreverent sense of humor. The Houston native earned his second career title shot behind a four-fight winning streak. 

Before making any picks of your own for UFC 265, make sure you see the MMA predictions from SportsLine analyst Ian Parker. He is coming off a mind-boggling 2020 season. On the Anik & Florian Podcast, Parker went an astounding 58-14, returning $9,465 to $100 bettors who followed him. He hit 11 of his 17 underdog picks and 19 of 30 main events. Overall, Parker nailed an astonishing 81 percent of his plays.

The former manager of several UFC fighters built on his impressive 2021 campaign with a 10-1 card at UFC 264, netting his followers a profit of nearly $900.  Anyone who has followed him is WAY UP! 

Now, he's turned his attention to UFC 265 and locked in his top picks. If you parlay them together, you're looking at a payout of of nearly 9-1! 

For UFC 265, we can tell you Parker is siding with Michael Chiesa (+110) to get his hand raised against Vicente Luque (-130) in a matchup of ranked welterweights on the main card. He's also backing one fighter who will "push the pace early and often" to score an upset! You ABSOLUTELY need to see his picks before locking in any UFC 265 bets of your own.

Who wins Gane vs. Lewis? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over at UFC 265, all from the ultimate MMA insider who returned nearly $9,500 last year!