Stipe Miocic will defend his heavyweight title on Saturday against top-rated contender Francis Ngannou in the main event of UFC 260 in Las Vegas. Their main UFC 260 fight card starts at 10 p.m. ET. Ngannou is a -125 favorite (risk $125 to win $100), while Miocic is a +105 underdog (risk $100 to win $105) in the latest Miocic vs. Ngannou 2 odds from William Hill Sportsbook. 

Before making any UFC 260 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 25 months, $100 bettors who have followed Marley's picks are up more than $20,000. The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 28 of his last 42 UFC main-event picks, a stretch that included a streak of five consecutive underdogs!

At UFC Fight Night last weekend, Marley notched another winner when he told SportsLine members to back Max Griffin (-190) against Kenan Song (+170) n a welterweight matchup on the main card.. Anyone who has followed Marley is WAY UP! 

This week at UFC 260, we can tell you Marley is backing Abu Azaitar (-110) to get his hand raised against Marc-Andre Barriault (-110) in a matchup of middleweight prospects. He's also backing a "faster fighter who will more volume and has a better chance at a knockout!" You ABSOLUTELY need to see Marley's other UFC Fight Night picks before making any of your own.

Who wins Miocic vs. Ngannou 2 and every bout on the UFC 260 card? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $20,000 on MMA picks and has nailed a whopping 28 of the last 42 main events!