The Portland Trail Blazers will take on the Los Angeles Lakers at 10 p.m. ET on Wednesday at the Moda Center at the Rose Quarter. Portland is 21-34 overall and 14-16 at home, while Los Angeles is 26-29 overall and 9-16 on the road. The Trail Blazers are ranked fourth in the Northwest Division; Los Angeles is ranked fourth in the Pacific Division. 

Los Angeles is favored by 9.5 points in the latest Trail Blazers vs. Lakers odds from Caesars Sportsbook, while the over-under is set at 223.5. Before you make any Lakers vs. Trail Blazers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 17 of the 2021-22 NBA season on a stunning 65-36 roll on all top-rated NBA picks, returning almost $2,400. Anyone following it has seen huge returns.

Now, it has simulated Trail Blazers vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Trail Blazers vs. Lakers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.