The unbeaten 49ers visit the upstart Cardinals on Thursday Night Football, with kickoff set for 8:20 p.m. ET. San Francisco is a 10-point favorite and the over-under is 43.5.

Before you make your 49ers vs. Cardinals picks, you need to see what SportsLine expert Zack Cimini has to say. Cimini is a highly respected Las Vegas handicapper who's never afraid to buck conventional wisdom. Last season, he hit 60 percent of his NFL selections for SportsLine members, and he enters Thursday Night Football on an amazing streak: He's nailed six straight against the spread picks for or against Arizona!

Now, Cimini has posted his another confident pick for 49ers vs. Cardinals. We can tell you he's leaning Under, but his much stronger pick is against the spread. You NEED to see his pick before locking in any of your own.

Who wins 49ers vs. Cardinals? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Cardinals spread you should jump on Thursday, all from the unconventional expert who has nailed six straight picks involving Arizona!