The Buffalo Bills (6-4) and New Orleans Saints (5-5) will meet on Thanksgiving for a primetime battle between playoff contenders. Buffalo is coming off a disappointing loss at home to the Indianapolis Colts, while New Orleans dropped its third straight game and lost to the Philadelphia Eagles, 40-29. 

Kickoff from Caesars Superdome is set for 8:20 p.m. ET on Thursday. Buffalo is favored by seven points in the latest Bills vs. Saints odds from Caesars Sportsbook, while the Over-Under is 45. Before making you make any Bills vs. Saints picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows Buffalo quarterback Josh Allen is sixth in passing yards (2,811), fifth in passing touchdowns (21), and ninth in QBR (58.8). The Wyoming product has thrown over 300 yards in four games this season while tossing at least two passing touchdowns in eight games.

The model also knows Saints quarterback Trevor Siemian has 920 passing yards with eight passing touchdowns on the year. He has thrown at least two passing touchdowns with over 200 yards in all three starts thus far. The Saints' offense has gone over 370 total yards in two of the last three games. 

Now, the model has set its sights on Bills vs. Saints on Thanksgiving Day 2021. We can tell you it's leaning under the total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any Bills vs. Saints picks of your own.

So who wins Bills vs. Saints on Thanksgiving? And which side of the spread has ALL the value? ... Join SportsLine right now to see which side of the Bills vs. Saints spread to back, all from the dialed-in NFL model that's up almost $7,500 on top-rated picks!