The Syracuse Orange will take on the No. 6 Villanova Wildcats at 9 p.m. ET Tuesday. The game is part of the 2021 Jimmy V Classic and will take place at Madison Square Garden. The Wildcats are 6-2 while 'Cuse is 5-3. The Orange and Villanova are both first in their respective divisions (the ACC and the Big East). 

The Wildcats are favored by eight points in the latest Syracuse vs. Villanova odds from Caesars Sportsbook, and the over-under is set at 143.5. Before you make any Villanova vs. Syracuse picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Syracuse vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Syracuse vs. Villanova? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!