The second-ranked Notre Dame Fighting Irish (9-0) must simply avoid an epic mistake at home against the Syracuse Orange (1-9) in Saturday's ACC matchup to stay on track for a College Football Playoff berth. Kickoff is set for 2:30 p.m. ET in South Bend, Ind. The Fighting Irish are 34-point favorites in the latest Syracuse vs. Notre Dame odds from William Hill Sportsbook, while the over-under is 50.5. (Head over to our college football odds page for the latest college football lines for this week's games).

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