Red Sox vs. Nationals odds, line, start time, picks, best bets for Friday, July 4, Interleague matchup from proven model
SportsLine's projection model, which is on a profitable 39-30 run on top-rated MLB picks, has locked in its MLB picks for the Red Sox vs. Nationals on Friday morning
The Boston Red Sox will battle the Washington Nationals in an interleague matchup on Friday morning. Both teams are coming off interleague series wins. The Red Sox (43-45), who are fourth in the American League East, are 18-25 on the road this season. The Nationals (37-50), fifth in the National League East, are 18-25 on their home field in 2025.
First pitch for the Fourth of July clash from Nationals Park in Washington, D.C., is set for 11:05 a.m. ET. The Nationals have won four of the last six meetings with the Red Sox. Boston is a -113 favorite on the money line (risk $113 to win $100) in the latest Red Sox vs. Nationals odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5 in the latest MLB odds.Â
Before you make any Red Sox vs. Nationals picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following could have seen strong returns!
The model has simulated Red Sox vs. Nationals 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!
Who wins Red Sox vs. Nationals, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 39-30 roll on top-rated MLB picks!
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