A Big Ten battle is on tap between the Purdue Boilermakers and the Illinois Fighting Illini at 3:30 p.m. ET on Saturday at Ross-Ade Stadium. Purdue is 2-1 overall and 1-0 at home, while Illinois is 1-3 overall and 0-1 on the road. This will be the Boilermakers' first conference game while Illinois is 1-1 in the Big Ten.

The Boilermakers are favored by 11 points in the latest Purdue vs. Illinois odds from Caesars Sportsbook, and the over-under is set at 53. Before you make any Illinois vs. Purdue picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns!

Now, it has simulated Purdue vs. Illinois 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins llinois vs. Purdue? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!