Pittsburgh vs. No. 25 Florida State odds, line: 2025 college football picks for Week 7 predictions from proven model

SportsLine's model has locked in its best bets for Saturday's ACC game between the Pittsburgh Panthers and Florida State Seminoles

Daniel Kohn

The 25th-ranked Florida State Seminoles look to snap a two-game losing streak when they battle the Pittsburgh Panthers in a key Atlantic Coast Conference matchup on Saturday. Pittsburgh is coming off a 48-7 win over Boston College, while Florida State dropped a 28-22 decision to Miami last week. The Panthers (3-2, 1-1 ACC), who are tied for sixth in the conference, are 0-1 on the road this year. The Seminoles (3-2, 0-2 ACC), who are 16th in the league, are 3-1 on their home field in 2025.

Kickoff from Doak Campbell Stadium in Tallahassee, Fla., is at noon ET. Pittsburgh leads the all-time series 6-5. The Seminoles are 10-point favorites in the latest Pittsburgh vs. Florida State odds, while the over/under for total points scored is 57.5 via SportsLine consensus. 

Before making any Pittsburgh vs. Florida State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Pittsburgh vs. Florida State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in over 60% of simulations!

So who wins Pittsburgh vs. Florida State, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!