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Panthers vs. Cardinals prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 4, 2022

The SportsLine projection model simulated Arizona vs. Carolina and released its picks, predictions and best bets
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The Carolina Panthers will take on the Arizona Cardinals in a NFC tilt at 4:05 p.m. ET on Sunday at Bank of America Stadium in Charlotte. Both teams are 1-2; the Panthers are 1-1 at home, while Arizona is 1-0 on the road. The Panthers, led by Baker Mayfield, are coming off an impressive 22-14 win over the New Orleans Saints, while Kyler Murray and the Cardinals are looking to bounce back from a 20-12 Week 3 loss to the Los Angeles Rams. 

Carolina is a 1-point favorite in the latest Panthers vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 43.5. Before you make any Cardinals vs. Panthers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Panthers vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread has ALL the value. You absolutely need to see it before locking in your own picks.

So who wins Panthers vs. Cardinals? And which side of the spread has ALL the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.

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SportsLine Staff

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