Two NFC division winners from last season, the Green Bay Packers and New Orleans Saints, begin their season on Sunday in Jacksonville, Fla. The game was moved from New Orleans due to damage from Hurricane Ida. Kickoff is 4:25 p.m. ET. Green Bay is a 3.5-point favorite in the latest Packers vs. Saints odds from Caesars Sportsbook while the Over-Under for total points scored is 49.5. (See the latest NFL lines for every game this week on our NFL odds page.)

Before you make any Saints vs. Packers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model knows Packers quarterback Aaron Rodgers is coming off an incredible season. He led the NFL with 48 passing touchdowns, a career-high, and completed 70.7 percent of his passes, also a career-high. He directed Green Bay to the NFC Championship game for the second straight season and won his third MVP award.

The model also knows Saints quarterback Jameis Winston enters Week 1 off an impressive preseason performance against Jacksonville. The former Buccaneers starter and last season's backup in New Orleans, Winston completed 9-of-10 passes for 123 yards and two touchdowns in the team's second preseason game. After the game he was named the team's starter.

Now, the model has set its sights on Packers vs. Saints. We can tell you it's leaning Over the total, and it also says one side of the spread cashes in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks of your own.

So who wins Saints vs. Packers on Sunday? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to find out which side of the Packers vs. Saints spread you should be all over, all from the advanced model that has returned almost $7,900 on top-rated NFL picks!