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Ohio State vs. Indiana odds, line, spread: Proven model reveals college football picks, predictions for Week 8

The SportsLine projection model has simulated Ohio State vs. Indiana and just revealed its CFB picks
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A Big Ten battle is on tap between the Indiana Hoosiers and the Ohio State Buckeyes at 7:30 p.m. ET on Saturday, October 23 at Memorial Stadium. IU is 2-4 overall and 1-2 at home, while OSU is 5-1 overall and 2-0 on the road. 

The Buckeyes are ranked first in the East Division; the Hoosiers are ranked sixth. The Buckeyes are favored by 19 points in the latest Indiana vs. Ohio State odds from Caesars Sportsbook, and the over-under is set at 60. Before you make any Ohio State vs. Indiana picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Indiana vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Indiana vs. Ohio State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!

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SportsLine Staff