An ACC battle is on tap between the Notre Dame Fighting Irish and the Louisville Cardinals at 7 p.m. ET on Wednesday at Purcell Pavilion at the Joyce Center. Notre Dame is 16-7 overall and 9-1 at home, while Louisville is 11-12 overall and 2-6 on the road. The Fighting Irish are ranked first in the ACC; Louisville is ranked tenth. 

The Fighting Irish are favored by 7 points in the latest Notre Dame vs. Louisville odds from Caesars Sportsbook, while the over-under is set at 135.5. Before you make any Louisville vs. Notre Dame picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Notre Dame vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Louisville? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.