A Big Ten battle is on tap between the Northwestern Wildcats and the Purdue Boilermakers at 12 pm ET on Saturday at Wrigley Field. Purdue is 6-4 while Northwestern is 3-7. The Boilermakers are ranked third in the West Division; the Wildcats are ranked sixth. 

The Boilermakers are favored by 12 points in the latest Northwestern vs. Purdue odds from Caesars Sportsbook, and the over-under is set at 48.5. Before you make any Purdue vs. Northwestern picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Northwestern vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Northwestern vs. Purdue? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!