No. 3 Miami vs. No. 18 Florida State prediction, odds, line, spread, start time: Proven Football expert makes his CFB Week 6 picks, best bets

Heated rivals battle in a key Atlantic Coast Conference matchup when the third-ranked Miami (Fla.) Hurricanes clash with the 18th-ranked Florida State Seminoles on Saturday night. Miami is coming off a 26-7 win over Florida on Sept. 20, while Florida State was upset by Virginia 46-38 in double overtime on Sept. 26. The Hurricanes (4-0, 0-0 ACC), who are 2-0 against ranked opponents this season, are playing their first road game of the year. The Seminoles (3-1, 0-1 ACC), who are 1-0 against ranked foes, are 3-0 on their home field in 2025.

Kickoff from Doak Campbell Stadium in Tallahassee, Fla., is set for 7:30 p.m. ET. Miami leads the all-time series 36-33, including a 36-14 win last season. The Hurricanes are 4-point favorites in the latest Miami vs. Florida State odds from SportsLine consensus, while the over/under for total points scored is 54.5. 

Before making any Miami vs. Florida State picks, you NEED to see what SportsLine expert Tom Fornelli has to say.

A CBS Sports writer since 2010, the entertaining Fornelli is perhaps best known for his college football expertise. Fornelli co-hosts the popular Cover 3 Podcast and appears regularly on CBS Sports HQ. You'll get maximum access to Fornelli's picks only on SportsLine. 

Fornelli's dedication to analysis of all levels of college football has helped him go 7-2 (+515) on his last nine picks in Miami (Fla.) games. Anyone who has followed him could be WAY UP!

Fornelli has analyzed Miami (Fla.) vs. Florida State and is leaning Under on the point total. He's also found a critical X-factor that has him jumping all over one side of the spread! 

Who wins Miami (Fla.) vs. Florida State and what critical X-factor has Fornelli jumping on one side of the spread? ... Join SportsLine right now to find out, all from an expert who returned $515 to $100 players over his last nine Miami (Fla.) picks!