No. 1 Ohio State vs. No. 17 Illinois odds, line: 2025 college football picks for Week 7 predictions from proven model

The top-ranked Ohio State Buckeyes will look to stay unbeaten when they take on the 17th-ranked Illinois Fighting Illini in a key Big Ten Conference matchup on Saturday. Ohio State is coming off a 42-3 win over Minnesota in Week 6, while Illinois downed Purdue 43-27. The Buckeyes (5-0, 2-0 Big Ten), who are in a four-way tie for first place in the conference, are 1-0 on the road this season. The Fighting Illini (5-1, 2-1 Big Ten), who are tied for fifth in the Big Ten, are 3-0 on their home field in 2025.

Kickoff from Memorial Stadium in Champaign, Ill., is at noon ET. Ohio State leads the all-time series 68-30-4, including nine in a row. The Buckeyes are 14.5-point favorites in the latest Ohio State vs. Illinois odds, while the over/under for total points scored is 50.5 via SportsLine consensus. 

Before making any Ohio State vs. Illinois picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Ohio State vs. Illinois 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread is the better value!

So who wins Ohio State vs. Illinois, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!