Drew Brees and the New Orleans Saints meet Justin Herbert and the Los Angeles Chargers on Monday Night Football. Kickoff is set for 8:15 p.m. ET. New Orleans is a seven-point favorite and the Over-Under is 50 in the latest Saints vs. Chargers odds from William Hill. Before making any Chargers vs. Saints picks of your own, you NEED to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Last year, he went 58-39 on his against-the-spread NFL picks, giving his followers a profit of more than $1,500.

He also has had a keen eye for the tendencies of the Chargers, posting a 7-1 record on his last eight picks involving the Chargers, a streak that goes back to December 2018. Anyone who has consistently followed him is WAY UP!

Now, he's studied Saints vs. Chargers from every possible angle. We can tell you he's leaning Over the total, and he's also found a critical X-factor that has him jumping ALL OVER one side of the spread! You ABSOLUTELY need to see it before you lock in your own picks.

So who wins Saints vs. Chargers on Monday Night Football? And what critical X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Chargers vs. Saints spread you should be all over on Monday, all from the seasoned expert who's 7-1 in his last eight picks involving the Chargers!