In the first Monday Night Football game of the 2019 preseason, the San Francisco 49ers visit the Denver Broncos at Broncos Stadium at Mile High to conclude Week 2. Kickoff is at 8 p.m. ET. The 49ers are one-point favorites with an Over-Under of 40.5. 

Before you make any 49ers at Broncos NFL Week 2 preseason picks, make sure you read what SportsLine expert R.J. White has to say.

White has been SportsLine's top pro football analyst for two-plus seasons. Over that span, the CBS Sports NFL editor and nationally recognized NFL Draft expert has gone 214-164 on against the spread picks, returning over $3,200 to $100 bettors. 

The stats guru, whose picks are coveted by fans everywhere, has cashed huge in the world's most prestigious handicapping tournament -- the Westgate Las Vegas SuperContest -- twice in the past four years. Anyone who has followed him is WAY UP.

White has scoured the rosters and made his picks for 49ers at Broncos. We can tell you he's leaning Over, but White has isolated a critical x-factor that has him going big on one side of the spread. You ABSOLUTELY need to see what it is before locking in any picks of your own. 

Who wins Monday's 49ers at Broncos preseason matchup? And which critical x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the 49ers at Broncos spread to back, all from the top-ranked NFL handicapper who's brought in more than $3,200 the last two seasons!