NFL odds, lines, spreads: 2025 Week 10 picks, predictions from proven model

Some NFL slates are a little better than others, and that's the case with the Week 10 NFL schedule. It's loaded with high-quality matchups to make Week 10 NFL picks on, including ascending teams that recently welcomed back their starting quarterbacks in Ravens vs. Vikings (+4.5). There's also a sneaky potential Super Bowl preview in Patriots vs. Buccaneers, which has Tampa favored by 2.5 points at home, per the latest NFL odds, despite New England being on a six-game win streak. A fierce divisional rivalry also takes place on Sunday with Rams vs. 49ers (+5.5) in the late afternoon window, as Mac Jones remains the starter in place of Brock Purdy, and L.A. looks to avenge an early-season loss to its divisional rival.

Sunday night features a potential AFC playoff preview with Steelers vs. Chargers (-2.5), and these teams have alternated wins and losses over their last six meetings. Monday night then has a potential NFC postseason preview with Eagles vs. Packers (-1.5). Many may lean towards Philly with both NFL spread predictions and on the money line as the Eagles have defeated the Packers in three straight.

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If, for some reason, you prefer underperforming teams to focus your NFL betting strategy on, then you're in luck. Jets vs. Browns could have ramifications for who picks first in next year's draft, and New York is at +2.5 per the Week 10 NFL spreads as that line has moved several points after the Jets traded away Quinnen Williams and Sauce Gardner on Tuesday.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 45-28 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 10 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 10 NFL picks is that the Bucs (-2.5, 48.5) cover at home versus the Patriots in a Sunday 1 p.m. ET kickoff. The model has Tampa prevailing versus the spread well over 50% of the time. Another one of its Week 10 NFL predictions: the 49ers (+5, 49.5) cover versus the Rams in well over 50% of simulations. The model also says the Under hits over 60% of the time in an A-rated O/U pick.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FOUR teams that cover in 60% of simulations or more! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 10, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 45-28 roll on top-rated NFL picks!

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