Monday Night Football will feature yet another divisional rivalry as the San Francisco 49ers host the Los Angeles Rams to close out Week 4. This will be the first meeting between the two NFC West foes since they met in the NFC Championship Game last season, with Los Angeles winning 20-17. Before making your NFL DFS picks on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top one percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to 49ers vs. Rams on Monday Night Football and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Monday Night Football is 49ers wide receiver Brandon Aiyuk. McClure's optimal NFL DFS strategy also includes rostering Rams receiver Cooper Kupp. The reigning NFL Offensive Player of the Year had 11 catches for 142 yards and two touchdowns in the NFC title game win over San Francisco and has topped the 100-yard mark in his last three games against the 49ers.

McClure is also targeting a player who could go off for MASSIVE numbers on Monday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Rams vs. 49ers on Monday Night Football? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!