The NFL will head to Mexico City when the San Francisco 49ers take on the Arizona Cardinals on Monday Night Football. With players like Christian McCaffrey, Deebo Samuel and DeAndre Hopkins, there will be no shortage of high-caliber NFL DFS picks for MNF. Before setting your NFL DFS lineups for Cardinals vs. 49ers on Monday Night Football, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

This year, he's already won the DraftKings Millionaire Maker twice and the FanDuel Million once! Now, McClure has turned his attention to 49ers vs. Cardinals and locked in his top daily Fantasy football picks.

We can tell you that Cardinals wide receiver DeAndre Hopkins is one of McClure's top NFL DFS picks for Monday Night Football. Part of McClure's optimal NFL DFS strategy also includes rostering 49ers running back Christian McCaffrey, who's already had 55 touches during his three games with the 49ers. He's turned those opportunities into 288 scrimmage yards, two rushing touchdowns, a receiving touchdown and a passing touchdown.

McClure is also targeting a player who could go off for MASSIVE numbers on Monday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for 49ers vs. Cardinals on Monday Night Football? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!