NFL DFS picks, 2025 NFL Sao Paulo Game: Chiefs vs. Chargers fantasy lineup advice, projections for DraftKings, Fanduel from Millionaire Maker contest winner

The Week 1 NFL schedule continues on Friday, September 5 with the 2025 NFL Sao Paulo game between the Kansas City Chiefs and Los Angeles Chargers (+3, 46.5). Kickoff is 8 p.m. ET at Corinthians Arena in Sao Paulo, Brazil. Big-name players such as Patrick Mahomes, Travis Kelce, Justin Herbert, and Ladd McConkey will headline the NFL DFS player pool, but history has proven that finding value in the lesser known players is a key to building successful Showdown NFL DFS lineups.

Before locking in any NFL DFS lineups or stacks for Chargers vs. Chiefs in the 2025 NFL Sao Paulo Game on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. 

Now, Kaylor has turned his attention to Chiefs vs. Chargers in the 2025 NFL Sao Paulo Game and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Chargers vs. Chiefs is Kansas City quarterback Patrick Mahomes. He's also rostering Chargers wide receiver Ladd McConkey, who burst on to the NFL scene as a rookie in 2024, catching 82 passes for 1,149 yards and seven touchdowns.

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for Chiefs vs. Chargers in the 2025 NFL Sao Paulo Game, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates