The San Diego Padres host the Minnesota Twins to kick off an intriguing three-game interleague series on Friday night as part of a 15-game MLB schedule. The Seattle Mariners will be trying to snap a four-game losing skid to AL West rivals the Houston Astros (8:10 p.m. ET). Meanwhile, the Tampa Bay Rays host the Cleveland Guardians (7:10 p.m. ET) in a matchup of AL Wild-Card contenders. The Twins are in first place in the AL Central, two games up on Cleveland. The Padres are second in the NL West, 12 games behind the Dodgers but second to the defending World Series champion Braves in the Wild-Card standings. 

First pitch for the Twins vs. Padres matchup at Petco Park is set for 9:40 p.m. ET. San Diego is the -130 favorite on the moneyline in the latest Padres vs. Twins odds from Caesars Sportsbook. The Twins are +115 underdogs, and the Over/Under for total runs is 7.5. 

The full 15-game Friday MLB schedule provides tons of opportunities for wagers, and you can cash in big if you combine your favorite picks in a parlay. (See up-to-date lines for every game on our MLB odds page.)

Before you make any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 284-243 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Friday, July 29. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 8-1! The parlay doesn't start until 8:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Twins +1.5 runs (-210) against the Padres, with Minnesota covering in 66 percent of simulations. Rookie right-hander Joe Ryan faces off against San Diego lefty Blake Snell in the series-opening matchup. 

The model has three other picks, including one team that is winning in almost 70 percent of simulations. You ABSOLUTELY need to see these picks before locking in any MLB picks of your own.

So which which team is winning almost 70 percent of the time is a MUST-BACK on Friday night? And which other teams do you need to unclude in a four-leg parlay for a payout of more than 8-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is 284-243 on top-rated MLB money-line picks since the start of the 2021 season!