Supremacy in the National League will be on the line when the top two teams in the league -- the rival Los Angeles Dodgers and San Francisco Giants -- open a massively important three-game series at Oracle Park in San Francisco. First pitch is 9:45 p.m. ET. The Dodgers are -115 money-line favorites in the latest Dodgers vs. Giants odds from Caesars Sportsbook, while the Giants are +105 underdogs. 

The game is one of 15 on Friday's loaded MLB schedule. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every game 10,000 times, is 176-142 on top-rated MLB money-line picks through 22 weeks in the 2021 season, returning almost $1,000. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has set its sights on the MLB schedule for Friday. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 24-1! The best part is that the parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Royals (-105) to beat the White Sox (8:10 p.m. ET). But the model has three other picks, including a big American League underdog pulling off an upset! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So which big American League underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 24-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is off to a fast start in 2021!