The top two teams in the National League West collide when the San Francisco Giants and San Diego Padres open a three-game series on Friday at Oracle Park in San Francisco. The Padres are -135 money-line favorites in the latest Padres vs. Giants odds from William Hill Sportsbook, while the Giants are +125 underdogs.

The game is one of 15 on Friday's loaded MLB schedule. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a profitable start in 2021, going 36-28 on top-rated MLB money-line picks through five weeks, returning almost $400. Anyone following it has seen huge rewards.

Now, the model has set its sights on the MLB schedule for Friday. Using its top picks for the day, the model has generated an EPIC four-leg parlay that would pay almost 22-1! The best part is that the parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Astros (-135) to beat the Blue Jays at 8:10 p.m. ET. But the model has three other picks, including a National League team pulling off a HUGE upset! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So which National League underdog is a MUST-BACK? And what other teams do you need include in your parlay for a HUGE 22-1 payout? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is off to a fast start in 2021!