The Penn State Nittany Lions will look to win their second consecutive game over the Michigan State Spartans for the first time in program history when they meet in Big Ten Conference action on Wednesday night. The Nittany Lions (6-2, 0-0), who will open up their conference slate, are also looking to improve to 5-0 on their home court this season. The Spartans (5-4, 0-1), who will be playing their first conference road game of the year, are 16-5 in games played at Penn State, although the Lions won last year's meeting 62-58. Michigan State has won 42 of the 52 meetings with Penn State.

The game from Bryce Jordan Center in University Park, Pa., tips off at 6:30 p.m. ET. Penn State is favored by 4 points at Caesars Sportsbook, while the over/under for total points is set at 136.5 (see up-to-date odds for every game this week on our college basketball odds page).

Before making any Michigan State vs. Penn State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns!

The model knows the Nittany Lions have four players averaging in double figures, led by senior guard Jalen Pickett. Pickett is averaging 16.1 points, 6.6 rebounds, 7.6 assists and 1.4 steals per game. He is hitting on 48.6% of his shots from the floor and 83.3% of his free throws. Pickett ranks fourth in the country in assist-to-turnover ratio (4.36) and fifth in assists, and is one of three active Division I players with 1,500 or more career points, 500-plus career assists and 500-plus career rebounds.

The model also knows the Spartans have been led by senior guard Tyson Walker. In nine starts this season, Walker is averaging 14.4 points, four assists, three rebounds and 1.3 steals per game. He is connecting on 44.3% of his field goals, including 38.2% from 3-point range, and 83.3% from the free throw line. He has reached double figures in seven of nine games, including a 22-point performance in a 73-71 win over Villanova at Gavitt Tipoff Games on Nov. 18.

Now, it has set its sights on Michigan State vs. Penn State. It is leaning Over on the total and it has also generated an against-the-spread pick that hits in 70% of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Michigan State vs. Penn State? And which side of the spread hits in 70% of simulations? ... Join SportsLine right now to find out which side of the Michigan State vs. Penn State spread you should be all over Wednesday, all from the model on a roll on college basketball picks!