A pair of top-10 teams face off Saturday in Columbus when the No. 4 Ohio State Buckeyes (9-1, 7-1 Big Ten) host the seventh-ranked Michigan State Spartans (9-1, 6-1) on Saturday. Kickoff from Ohio Stadium is set for noon ET. 

The Buckeyes are a 19-point favorite in the latest Michigan State vs. Ohio State odds from Caesars Sportsbook, while the over-under for total points scored is 69.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you consider your Ohio State vs. Michigan State picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The Buckeyes lead the nation in scoring at 46.3 points per game behind quarterback C.J. Stroud (3,036 yards, 30 TDs) and running back TreVeyon Henderson (1,035, 14 TDs). The Buckeyes also typically win the turnover battle, as they have 17 takeaways while turning it over just eight times. The OSU defense ranks 14th in the nation against the run (107 yards per game), so Spartans star Kenneth Walker will have his work cut out for him.  

Michigan State's offense is led by Walker, the nation's leading rusher with 1,473 yards and 17 rushing TDs (tied for first). The Spartans average 34.6 points (26th in FBS) and almost 451 yards (21st), with QB Payton Thorne throwing for 2,460  yards and 21 TDs. He could exploit an OSU defense that ranks 108th in the nation against the pass (261.5 yards per game). The MSU defense has 16 takeaways and 32 sacks, tied for 14th-most in FBS).          

The SportsLine model has simulated Michigan State vs. Ohio State 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the Michigan State vs. Ohio State matchup in Saturday's Big Ten showdown? And which side of the spread is hitting over 50 percent of the time? ... Join SportsLine right now to see which side of the Ohio State vs. Michigan State spread you need to jump on Wednesday, all from the computer model on a 36-23 run on its top-rated college football side picks!