Teams that are a combined 7-1 to open the season meet when the Michigan State Spartans take on the Loyola Chicago Ramblers in an opening-round matchup of the 2021 Battle 4 Atlantis on Wednesday. Tip-off from Imperial Arena in Nassau, The Bahamas, is set for noon ET. Michigan State is favored by 2.5 points at Caesars Sportsbook, while the over-under for total points is set at 138.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Loyola Chicago vs. Michigan State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows senior forward Gabe Brown leads the Spartans on offense, averaging a team-high 14 points, four rebounds and 1.8 steals per game. The co-captain has scored in double figures in all four games this season, including a season-high 19 points at Butler on Nov. 17. He also grabbed six rebounds in that game. He scored a game-high 17 points with seven rebounds in the Nov. 12 win over Western Michigan.

The model also knows the Ramblers are led by senior transfer forward Ryan Schwieger, who is averaging 14.8 points, 4.3 rebounds and two assists in just 18 minutes of action. He has connected on 51.4 percent of his field goals, including 50 percent from 3-point range on 8 of 16 shooting. Over his last two games, he is averaging 22 points, four rebounds and two assists. He played his first three collegiate seasons at Princeton, averaging 10.7 points, three rebounds and 2.6 assists as a junior. He is an 84 percent free throw shooter in his career.  

Now, it has set its sights on Loyola Chicago vs. Michigan State. It is leaning Over on the total and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Loyola Chicago vs. Michigan State? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Loyola Chicago vs. Michigan State spread you should be all over Wednesday, all from the model on a roll on college basketball picks!