The Louisville Cardinals will take on the South Florida Bulls at noon ET on Saturday at Cardinal Stadium. South Florida is looking to bounce back from a narrow loss to No. 18 Florida, while Louisville is coming off a loss to Florida State. The Cardinals are favored by 14.5 points in the latest Louisville vs. South Florida odds from Caesars Sportsbook, while the over/under is set at 64.5. 

Before you make any South Florida vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. South Florida? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!