The Cleveland Guardians and Chicago White Sox open a doubleheader with a matinee contest at 1:10 p.m. ET on Saturday. Chicago is listed as a -115 favorite (risk $115 to win $100) at Caesars Sportsbook, while the Over-Under is set at 8.5 (see up-to-date odds for every game this week on our MLB odds page). Before making any Guardians vs. White Sox picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 280-240 on top-rated MLB money-line picks since the start of the 2021 season, returning over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows the Guardians have offensive strengths, but pitching is at the forefront in this matchup. 24-year-old right-hander Triston McKenzie takes the ball for Cleveland, and he has a 3.20 ERA this season. McKenzie also has a 0.98 WHIP with 3.56 strikeouts for every walk. The young starting pitcher has been lights-out in July, throwing 21 innings without allowing an earned run and striking out 23 batters.

The model also knows the White Sox rank near the top of the American League in several categories. Chicago is in the top tier in hits, runs scored, doubles, batting average, and strikeout avoidance. The White Sox also deploy a top-five bullpen in the American League, with above-average marks in strikeout rate and ground ball rate. Chicago is facing a Cleveland offense that is in the bottom third of the AL in home runs and total bases.

Now, it has set its sights on Guardians vs. White Sox. We can tell you the model is leaning under the total, and it also says one team has all the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins Guardians vs. White Sox? And which team has all the value on the money line? ... Join SportsLine right now to find out which side of the Guardians vs. White Sox matchup you should be all over Saturday, all from the model on a roll on MLB picks!