The Memphis Grizzlies will take on the Cleveland Cavaliers at 8 p.m. ET on Wednesday at FedExForum. Memphis finished second in the Southwest Division last year at 38-34 and made the playoffs after clinching a play-in berth, while Cleveland placed fourth in the Central Division at 22-50. 

Memphis is favored by 7.5 points in the latest Grizzlies vs. Cavaliers odds from Caesars Sportsbook, and the over-under is set at 218. Before you make any Cavaliers vs. Grizzlies picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three seasons. The model finished up almost $600 on its top-rated picks last season and enters the 2021-22 NBA season on a stunning 100-66 roll on top-rated NBA picks against the spread. Anyone following it has seen HUGE returns!

Now, it has simulated Grizzlies vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Grizzlies vs. Cavaliers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks... If you're already a member, see the picks below!