Eagles vs. Giants prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 6 Thursday Night Football

The SportsLine projection model, which is 41-21 on top-rated picks since last season, reveals Giants vs. Eagles picks for Thursday Night Football in NFL Week 6

Ross Kelly

An NFC East battle takes place on 'Thursday Night Football' in Week 6 as the Philadelphia Eagles visit the New York Giants. The Eagles (4-1) are coming off their first defeat since before Christmas as they fell, 21-17, to the Broncos on Sunday. The Giants (1-4) couldn't string together a winning streak as they lost to Saints, 26-14, in Week 5 after notching their first victory the prior week. Philly has won 11 straight games versus the Giants in primetime and is 3-0 all-time versus New York on Thursdays. Darius Slayton (hamstring) is out for New York, while defensive tackle Jalen Carter (heel) is out for Philadelphia.

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Kickoff is at 8:15 p.m. ET from MetLife Stadium in East Rutherford, N.J. The latest Eagles vs. Giants odds have Philadelphia as the 7.5-point favorites. The over/under for total points is 40.5, a 3-point drop after opening at 43.5. The Eagles are a -400 favorite on the money line (risk $400 to win $100), while New York is priced at +311 (risk $100 to win $311).

Before making any Giants vs. Eagles picks or Thursday Night Football predictions, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Giants vs. Eagles on Thursday Night Football.

We can tell you the model is going Over the point total, but also says one side of the spread hits over 60% of the time in an A-rated pick! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Eagles vs. Giants in NFL Week 6, and which side of the spread hits over 60% of the time in an A-rated pick? ... Join SportsLine RIGHT NOW to see which side of the Giants vs. Eagles line to back, all from the model that is 41-21 on top-rated picks since 2024!

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