Eagles vs. Giants odds, line: 2025 NFL picks for Week 6 Thursday Night Football predictions from proven expert

Teams coming off losses clash in a key NFC East matchup, when the Philadelphia Eagles battle the New York Giants on Thursday Night Football. Philadelphia dropped a 21-17 decision to the Denver Broncos, while New York fell 26-14 at New Orleans this past Sunday. The Eagles (4-1), who are 3-0 in the NFC, are 2-0 on the road this season. The Giants (1-4), who are 0-3 in the conference and 0-2 in the division, are 1-1 on their home field in 2025. Giants quarterback Jaxson Dart (hamstring) is expected to play, although he could be hampered, while New York wideout Darius Slayton (hamstring) is out. Jalen Carter (heel) is out for Philadelphia, and Giants RB Tyrone Tracy Jr. (shoulder) is active.

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Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 8:15 p.m. ET. Philadelphia leads the all-time series 95-88-2, including wins in seven of the past eight meetings. The Eagles are 7.5-point favorites in the latest Eagles vs. Giants odds, while the over/under for total points scored is 40.5 via SportsLine consensus, after being as high as 43.5. The Under is a combined 7-3 for the teams this season. Philly is at -413 on the money line (risk $413 to win $100), with New York at +319 (risk $100 to win $319).

Before making any Eagles vs. Giants picks, be sure to check out what SportsLine expert Adam Silverstein has to say.

CBS Sports' managing editor, Silverstein is an expert on college and pro football and is coming off a second straight dominant NFL season. He went 100-75-7 (plus $1,749 for $100 players, every bet one unit) in the 2024 season, bringing his two-year run to 188-138-16 (plus $3,564).

Anyone following him has seen impressive returns.  He especially has the pulse of the Philadelphia Eagles. In his last 61 selections involving the Eagles, he is 37-22-2 (+1299)!

Now Silverstein has zeroed in on Eagles vs. Giants. 

He's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Eagles vs. Giants, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is on a sizzling 37-22 run on picks involving the Eagles!

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